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Search Results for " platelet collagen receptor "

3

抑制剂 & 化合物

1

天然产物

4

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T61697	GPVI antagonist 1
	GPVI antagonist 1 (compound 5) functions as an antagonist for the glycoprotein VI (GPVI) platelet receptor. It effectively inhibits collagen-induced platelet aggregation, demonstrating an IC50 value of 25.3 μM [1].
T35725	4-hydroxy Valsartan
	4-hydroxy Valsartan is a major metabolite of the angiotensin II type 1 (AT1) receptor antagonist valsartan . It reduces platelet aggregation induced by epinephrine and collagen but not ADP in human whole blood.
T36553	Thrombin Receptor Peptide Ligand (trifluoroacetate salt)
	Thrombin receptor peptide ligand is antagonist of the thrombin receptor (EC50s = 16-33 μM to inhibit platelet aggregation in vitro). It inhibits α-thrombin and platelet aggregation induced by thrombin receptor activating peptide in vitro when used at a concentration of 32 μM but does not affect platelet aggregation induced by ADP or collagen. It also inhibits thrombin- and TRAP-induced proliferation of vascular smooth muscle cells (VSMCs). Thrombin receptor peptide ligand (100 μmol/kg bolus, i.v...

化合物

GPVI antagonist 1

Cat.No: T61697

4-hydroxy Valsartan

Cat.No: T35725

Thrombin Receptor Peptide Ligand (trifluoroacetate salt)

Cat.No: T36553

Cat. No.	Product Name	Target	Signaling Pathways
T4S0498	Glaucocalyxin A 蓝萼甲素,Wangzaozin B,Leukamenin F	Apoptosis; Akt; Caspase; PI3K	Apoptosis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Glaucocalyxin A (Leukamenin F) 是来自日本黑纹病菌的一种对映型月桂基二萜，具有抗肿瘤作用。它通过调节PI3K/Akt 信号通路抑制 GLI1 的核易位，诱导骨肉瘤凋亡。

天然产物

Glaucocalyxin A

Cat.No: T4S0498

Synonym: 蓝萼甲素,Wangzaozin B,Leukamenin F

Target: Apoptosis, Akt, Caspase, PI3K

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00605	GPVI Protein, Mouse, Recombinant (His) Glycoprotein 6,GP6,glycoprotein VI (platelet),GPVI,...	Mouse	HEK293 Cells
	Glycoprotein VI (GPVI) is a 63 kDa platelet/megakaryocyte-specific type I transmembrane glycoprotein of the immunoglobulin superfamily that is an important collagen receptor and initiator of platelet activation, aggregation and thrombin generation. GPVI is also a secondary receptor required for platelet spreading on laminin. GPVI associates with the Fc receptor gamma -chain via charged aa in the TM domains of GPVI (arginine) and the FcR gamma (aspartic acid). Collagen binding by the GPVI Ig-like...
TMPJ-00292	CD36 Protein, Human, Recombinant (hFc) FATCHDS7,Glycoprotein IIIb,SCARB3,CD36,Fatty acid translocas...	Human	HEK293 Cells
	Platelet Glycoprotein 4 (CD36) is an integral membrane glycoprotein that has multiple physiological functions. It is broadly expressed on a variety of cell types including microvascular endothelium, adipocytes, skeletal muscle, epithelial cells of the retina, breast, and intestine, smooth muscle cells, erythroid precursors, platelets, megakaryocytes, dendritic cells, monocytes/macrophages, and microglia. As a member of the scavenger receptor family, CD36 is a multiligand pattern recognition rece...
TMPH-00213	Disintegrin batroxostatin Protein, Bothrops atrox, Recombinant (His & Myc) Platelet aggregation activation inhibitor,Disintegr...	Bothrops atrox	E. coli
	Inhibits fibrinogen interaction with platelets. Acts by binding to the glycoprotein IIb-IIIa receptor (ITGA2B/ITGB3) on the platelet surface and inhibits aggregation induced by ADP, thrombin, platelet-activating factor and collagen. Also inhibits T24 and SK-Mel-28 cell adhesion to fibronectin with IC(50) of 4.4 uM and 33 nM, respectively. Disintegrin batroxostatin Protein, Bothrops atrox, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted...
TMPH-02974	Von Willebrand Factor/vWF Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. Von Willebrand Factor/vWF Protein, Mouse, Recombinant (His & Myc) is expressed in E....

重组蛋白

GPVI Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00605

Species: Mouse

Expression System: HEK293 Cells

CD36 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00292

Species: Human

Expression System: HEK293 Cells

Disintegrin batroxostatin Protein, Bothrops atrox, Recombinant (His & Myc)

Cat.No: TMPH-00213

Species: Bothrops atrox

Expression System: E. coli

Von Willebrand Factor/vWF Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02974

Species: Mouse

Expression System: E. coli

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